Recently in Temperature Regulation In Burned Patients Category

May 19, 2011

New treatment for regulating body temperature and pain management in burn patients


Cumberland Pharmaceuticals Inc. announced in mid-May that results from a clinical study evaluating the safety and efficacy of Caldolor (ibuprofen) given intravenously to treat fever and pain in hospitalized burn patients was published in Volume 32, Number 1 of the Journal of Burn Care & Research.

The study demonstrated that Caldolor significantly reduces fever in these patients, including those with severe thermal burns. The newly published study also supports the safety of Caldolor as it involved the highest dose and duration of exposure to IV ibuprofen to date, demonstrating that the recommended maximum daily dose of 3200 mg/day over five days of treatment was well tolerated.

"Immediate and sustained regulation of body temperature and reduction of fever following a burn injury is critical to patient recovery as well as comfort," said Dr. John T. Promes, principal investigator of the study, Director of Trauma Services and Associate Director for Surgical Education at Orlando Regional Medical Center.

"Because oral administration in hospitalized burn patients is often impossible due to sedation, intubation or other factors, fever reduction with an IV agent such as Caldolor is often necessary." Further, as a non-steroidal anti-inflammatory drug (NSAID), Caldolor has the potential to stop the escalation of inflammation caused by burn injury and alleviate pain in addition to fever.

The trial was conducted at five U.S. and international sites, including hospital burn units and burn centers. The study evaluated 61 adult burn patients with second-degree or third-degree burns covering more than 10 percent total body surface area with an anticipated hospital stay of more than 72 hours and fever of 100.4 degrees or greater. Patients were administered 800 mg of Caldolor every six hours for five consecutive days. There was a significant reduction in temperature in the first 24 hours of treatment in patients receiving Caldolor compared with those receiving a placebo. Caldolor was well tolerated and there was no significant difference in adverse events between patients receiving placebo and those receiving Caldolor.

According to the American Burn Association, 1.1 million burn injuries require medical attention each year in the United States. Of these, approximately 50,000 burn injuries require hospitalization, 20,000 are major burn injuries affecting 25 percent of total body surface area and 4,500 people die. In addition, up to 10,000 people in the United States die every year from burn-related infections.

Caldolor is indicated for the management of mild to moderate pain and management of moderate to severe pain as an adjunct to opioid analgesics, and for the reduction of fever in adults. It is the first FDA approved intravenous therapy for fever.

March 22, 2010

Temperature Regulation In Burned Patients

The skin plays an important role in body temperature regulation, see regulation of body temperature. In deep second degree and in third degree burns, the sweat glands will be destroyed and will not be replaced by new ones as the skin heals. These patients will often have difficulty in humid and hot situations (because of the destruction of sweat glands which play a role in regulating the body temperature).

These patients have to be careful and avoid certain exercise, activities or working conditions that might lead to heat stroke (heat stroke is an abnormally increased body temperature with accompanying physical and neurological symptoms). They are susceptible to heat stroke because the sweat glands are destroyed.

People with Partial thickness skin grafts may not fully recover sweat glands; this may cause problems with temperature regulation as well.

This information is not intended nor implied to be a substitute for professional medical advice; it should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Call 911 for all medical emergencies.