Articles Posted in Temperature Regulation In Burned Patients

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Cumberland Pharmaceuticals Inc. announced in mid-May that results from a clinical study evaluating the safety and efficacy of Caldolor (ibuprofen) given intravenously to treat fever and pain in hospitalized burn patients was published in Volume 32, Number 1 of the Journal of Burn Care & Research.

The study demonstrated that Caldolor significantly reduces fever in these patients, including those with severe thermal burns. The newly published study also supports the safety of Caldolor as it involved the highest dose and duration of exposure to IV ibuprofen to date, demonstrating that the recommended maximum daily dose of 3200 mg/day over five days of treatment was well tolerated.

“Immediate and sustained regulation of body temperature and reduction of fever following a burn injury is critical to patient recovery as well as comfort,” said Dr. John T. Promes, principal investigator of the study, Director of Trauma Services and Associate Director for Surgical Education at Orlando Regional Medical Center.

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The skin plays an important role in body temperature regulation, see regulation of body temperature. In deep second degree and in third degree burns, the sweat glands will be destroyed and will not be replaced by new ones as the skin heals. These patients will often have difficulty in humid and hot situations (because of the destruction of sweat glands which play a role in regulating the body temperature).

These patients have to be careful and avoid certain exercise, activities or working conditions that might lead to heat stroke (heat stroke is an abnormally increased body temperature with accompanying physical and neurological symptoms). They are susceptible to heat stroke because the sweat glands are destroyed.

People with Partial thickness skin grafts may not fully recover sweat glands; this may cause problems with temperature regulation as well.